Scientific Leadership

Science & Expertise

Scientific authority is our foundation, not our afterthought.

Human-in-the-loop AI workflows Peer-reviewed scientific output Trial-ready evidence and case studies

Our Approach

Evidence-driven ophthalmic imaging, built for accuracy, quality, and operational confidence.

Our science team combines expert graders, validated workflows, and AI-assisted review to deliver defensible outcomes for modern clinical trials.

Scientific Philosophy

"We do not move fast and break things. We move fast and get it right."

Human-in-the-loop AI: AI flags. Our experts decide. OIRRC uses AI to accelerate workflows, but expert human judgment is always in the loop.

Quality & Accuracy: Dual read + adjudication standard. Every read is verified, every endpoint is validated.

Compliance Posture: OIRRC has established and operates under robust data security and compliance frameworks aligned with ISO 27001, HIPAA, GDPR, and 21 CFR Part 11 requirements.

"AI-Powered. Human-Verified. Trial-Ready."

Research First

Every algorithm, every read, every endpoint is validated against peer-reviewed science.

41
Publications

3
Case Studies

100+
Investigators

3
Continents

Therapeutic Areas

AMD (wet & dry)

Fluid monitoring, drusen mapping, geographic atrophy, and longitudinal imaging endpoints.

Stargardt Disease

FAF-based atrophy mapping, IGMP overlay, and EZ integrity assessment workflows.

Diabetic Retinopathy

DRSS grading, lesion mapping, ultra-widefield imaging, and AI-assisted review support.

Diabetic Macular Edema

Fluid quantification, retinal thickness tracking, and treatment response endpoints.

Uveitis

Vitreous haze grading, anterior and posterior segment imaging, and endpoint adjudication.

Corneal Edema & Dystrophy

Endothelial cell density, morphology, and specular microscopy review workflows.

Research Library

Peer-Reviewed Publications

Browse OIRRC-associated publications by year, therapeutic focus, and study design. The library is built for sponsors, investigators, and partners who want a fast read on our scientific depth.

41 Total publications

2026 Latest year

31 Research topics

Featured publication Diabetic Macular Edema Preprint / Post-hoc analysis

Treating Vision, Not Signs: A Post-hoc Analysis Evaluating BCVA as an Early Indicator in Treat-and-Extend Management of DME (preprint)

Khowaja AH, Janjua K, Ali H, Afridi R, Fazal ZZ, Shaik MAS, Ahmed MI, Halim MS, Leng T, Pan CK, Nguyen QD, Sepah YJ

medRxiv 2026 Feb

View DOI PubMed

41 publications

Case Studies

Real results. Anonymized for confidentiality.

Wet AMD

Phase I/IIa Wet AMD Trial: Multiple Protocol Re-designs

A Phase I/IIa wet AMD trial required multiple protocol re-designs across the study duration.

Approach: OIRRC held the timeline through each iteration, adapting imaging protocols and eligibility criteria.

Outcome: On-time database lock, zero deviations, successfully met all endpoints.

Geographic Atrophy

Phase III Geographic Atrophy: 4-Week Site Activation

Global Phase III GA trial needed rapid site activation across 3 continents within 6 weeks.

Approach: OIRRC deployed Clarity for remote BCVA certification, eliminating in-person visits.

Outcome: 42% faster site activation, 40+ sites certified within 4 weeks.

Diabetic Macular Edema

Emerging Biotech: First-in-Human Readiness

Emerging biotech needed IRB-ready imaging workflows for a first-in-human DME trial.

Approach: OIRRC delivered protocol design, device certification, and eligibility workflow.

Outcome: FDA meeting-ready within 2 weeks, trial launched on schedule.

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